Magnesium - a strong anti-depression essential mineral

A Natural Strong Anti-depressant

When someone was treatment-resistant to something, we used to think that a doctor or specialist just had not found the right medication or chemical for that particular disease or person. Then, over time, we came to see that in some cases, medications are trial and error.
Thinking more holistically led to scrutinizing imbalances rather than assuming that someone was pharmaceutically lacking. The obvious need to address the underlying cause(s) and imbalance(s), rather than trotting out chemical band-aids became recognized. An example of addressing serious nutritional imbalances, would be Dr. Abram Hoffer's great ortho-molecular work in regards to depression, bi-polar, shizoprenia, etc. His work never received it's deserved due and is thoroughly discussed at 

Also the research work at TrueHope relates to rebalancing with micronutrient interventions rather than medicating -

An important cog in the mental-health-wheel is a full-blown magnesium deficiency. A serious lack is not hard to come by. It takes a few decades for most of us to obtain a serious magnesium systemic deficiency. This deficiency is then further aggravated by the known (but ignored) side-effects of many lucrative medications - ohhhh - so heart-breaking! Then we see imbalances from this for which we have many interesting names and labels and pharmaceuticals to match - such as fibromyalgia - as an example!

And it's not just our bodies that suffer needlessly. There's your mind, too - believe it or not!
A magnesium deficiency leads to an over-abundance of N-methyl-d-aspartate (NMDA). NMDA is a substance that is not normally found in healthy tissue. Cerebral spinal fluid contains magnesium (sometimes called brain magnesium) and has been found to be too low in drug-resistant depression, as well as with other depression oriented diagnoses. Many research projects have come to similar results in sussing out magnesium levels in sufferers. (In fact initial research goes back to the 1920's and shows 88% success rates in both animals and human experiments where magnesium levels were corrected.)
But magnesium is not patentable! No money to be made here - so no remarkable stories to tell! Only in the last few decades has this research been minimally re-activated. Magnesium's brilliant role in mental health re-balancing is now common knowledge in research circles and well reported at PubMed type libraries - and has not filtered down any farther. It just doesn't filter down to the GP level and the to the people who NEED to know the details and how to use this mineral. Could it be because a GP doesn't know how magnesium supplements actually work (it's not just about taking any old supplement with the word magnesium on the label...) and how our bodies absorb efficiently and that they cannot be seen administering magnesium IV's either - too time consuming as a visit needs to be wrapped up in 10 minutes and then the suspicion of thinking too much like being a naturopath?
Naturopaths hopefully are on the ball with all of this! (Doctors are kept up-to-date mainly by medication sales people - not supplement researchers.)

Back to NMDA - this excitotoxin's over-presence (due to a lack of magnesium) is over-kill for our bodies. Over-exciting our nerve cells becomes a problem with exaggerated quantities and leads to brain lesions. (And this is where the addition of unfermented soy becomes an even further exacerbating problem.)
NMDA activates receptors on nerve cell membranes and rendered them temporarily off their rockers. Calcium and sodium ions can then pass into the affected nerve cell and also then lets potassium out of this cell. A healthy cell would want the opposite to occur - and this reverse action causes all sorts of "hay-wire" signalling - a disruption with a wide range of delicate physiological (such as memory loss, for example) and pathological (such as increased agitation, for example) processes.

A 2008 randomized clinical trial showed that magnesium was as effective as tricyclic anti-depressants in treating depression and/or pain (such as Amitriptyline, Imipramine, Clomipramine, Doxepin, Nortriptyline, Desipramine) and results were FAST.

Intravenous and oral magnesium, properly ministered with specific protocols, have been reported to rapidly terminate depression including those "drug" resistant depressions. No side effects were reported! (And with the possible benefits of happier muscles and less chronic pain and fatigue).
Magnesium's deficiency is not foremost on our minds especially when we are chronically unwell but eat right and take supplements. But consider that magnesium has been largely removed from most diets and foods due to processing.
When we DO consume it, magnesium cannot be absorbed due to the many medications that "protect" the oesophagus and stomach and God knows what else… such as Omeprazole (Prolosec), Tagament, Pepsid, Zantac, Lansoprazole (Prevacid) and Metformin, just to name a few.  
Unfortunately popping an occasional cal/mag pill won't do the trick. Magnesium needs a very specific stomach environment to absorb (and that needs to be co-ordinated wisely). Calcium absorption needs it's own very specific details in place (such as co-factors in the small intestinal tract affecting its 21 feet and millions of villi) to be efficiently absorbed. And the optimal conditions for calcium and magnesium are almost opposites and definitely cannot be achieved with one pill with combined minerals. (Yes! Expensive urine is created from the advertising for cal/mag pills!) Needless to say, the magnesium for a multi-vitamin isn't going anywhere.
What were these manufacturing companies thinking? Maybe each molecule in each cal/mag pill and multi-vitamin has a GPS attached with a note as to where to go and I missed this piece…)
Glutamate, aspartate and many unpronounceable items are now "legally" inserted into processed foods. This may worsen the brain-nerve-synapses disorders and lesions that add to the depression. These addictives and additives have crept into our foods stealth-fully. If you lauded the folks who make Mars bars for not adding artificial sweetener poisons (which I did) and then find that they do actually add aspartame, but call it "natural flavouring", then, you too, were tricked.
But the trick penetrates deeper than just eating a toxin that has to be eliminated. The toxin has effects on many other chemical processes, that in turn affect other processes and so the dominoes go. 
Magnesium deficiency should not be guessed at. The symptoms are many and overlap with so many other possibilities and symptoms. Magnesium deficiency can be seen with properly practiced Live Blood Analysis. 


Best qi,
Merrie Bakker B.Sc, M.Arch, CN


we’re in Kerrisdale, Vancouver, BC
by appointment only
please email, phone or text 604-261-7742,

HOURS: flexible hours - Monday - Saturday
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Merrie Bakker - Live Blood Analyst / microscopist - Health Educator - Author - Teacher - Speaker - Editor - Hands-on-Healer - Reflexologist - Dowser - Reiki Master - Nutritional Coach - a life-long student of holistic medicine and preventative health who believes with a passion that cellular disorganization can be prevented or reversed by ortho-molecular medicine, emotional healing work, environmental detoxification (many areas of concern) and nutritional and lifestyle re-balancing (many possibilities). Combined with vigilance, monitoring and team work, clients are encouraged to detox, rebuild, re-nourish, resolve and re-educate.


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Only medical doctors are legally allowed to diagnose and treat any named diseases but with live blood analysis and no-guessing nutrition, we may be able to help alleviate or shed light on many of the related underlying reasons for symptoms and find root causes.  We have 23 years of experience in nutritional microscopy and it's interpretation with dark field, brightfield and phase contrast.

Obligatory medical disclaimer:
It should go without saying... but we know and you know that you take full legal responsibility for whatever decisions you make regarding your health care.
What we offer on this site is for informational purposes only and is not intended as medical advice. The whole point here is that you think clearly for yourself and make your own decisions.


I thought I’d give live blood cell analysis one more try with Pacific Holistic... I had this process done once before and was in awe of seeing my blood magnified onto a monitor. I was less impressed by the practitioner, whose nutritional education was lacking but not his resolve to take me and my long list of required supplements to a nearby health store and then to find out that this practitioner was actually an employee of the store, as well! Ms. Bakker makes suggestions for subtle lifestyle changes, new food choices and learning more, first. This isn’t earth shattering but tailored uniquely to me and then there’s a list with priorities and suggestions as to supplements and which brands and possible stores in the Lower Mainland that carry these brands – and I’m free to proceed as I wish. Her report and summary are thorough and honest and good to refer back to.

George Hugh J.

By using Pacific Holistic, information / service either via the internet, email, in person or phone, you are deemed to consent to the terms and conditions of the following disclaimer: You hereby agree that you voluntarily seek the alternative health care services from Merrie Bakker that are intended to complement, not replace, the advice of your own physician or other healthcare professionals.
All information that is provided by Merrie Bakker online and elsewhere, is done so in an effort to educate and is complementary and holistic in nature.